Southeast Texas Medical Associates, LLP Healthcare Where Your Health is the Only Care Southeast Texas Medical Associates, LLP

EPM Tools - Progression to Diabetes - Insulin Resistance
Print this page

Insulin resistance increases the secretory function of the B-cell.

  • The idea that this leads to B-cell exhaustion may not be a fact.  The following argue against that.
  • First, insulin resistance is common, occurring in almost all obese subjects.  Even so, only a small proportion of obese individuals ultimately develop diabetes.
  • Second, the Pima Indian study highlights the fact that B-cell function is enhanced in apparently health subjects as insulin resistance progresses.
  • Third, induction of short-term experimental insulin resistance with nicotinic acid is associated with adaptive increase in B-cell function manifested as increased insulin release and a decrease in proportion of proinsulin in plasma.
  • Therefore, it would seem that a failure to adequately adapt to insulin resistance may be due to a genetically programmed B-cell abnormality associated with an inability of the normal B-cell to adapt to insulin resistance and increased secretory demand thus uncovering a defect in B-cell function.
  • On the other hand, the B-cells in those without such a genetic issue would adapt and prevent the development of hyperglycemia.

2929 Calder
3570 College
Mark A. Wilson Clinic
2010 Dowlen
2400 Highway 365
610 Strickland Drive
137 N LHS Drive

409-833-9797 888-833-0523

Office Hours: Monday through Thursday 8:00 AM to 5:30 PM and Friday 8:00 AM to 12:00 PM
If you need information about your healthcare, you may contact us by phone 24 hours a day, 7 days a week.